How do you get people to reply to you?
Focus on your recipient
You'll probably increase your chances of getting a response if you focus on the recipient instead. Talk about their problems. Talk about their needs. Make it clear to them how they're going to benefit if they choose to respond to you.
What happens if you reply to a auto generated email?
First it will check if there is any mailbox, or account related to that email id. If found exchange will route that email to the destination. Incase the account has delivery restriction applied message will be rejected you might receive an NDR. If the email id doesn't exist you will get an NDR as well.