Indicating a folded state

1. What is folded state?
2. What are folds in bioinformatics?
3. What is the native folded state of a protein?
4. What is two-state folding?

What is folded state?

Folded proteins are held together by various molecular interactions. During translation, each protein is synthesized as a linear chain of amino acids or a random coil which does not have a stable 3D structure. The amino acids in the chain eventually interact with each other to form a well-defined, folded protein.

What are folds in bioinformatics?

Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional.

What is the native folded state of a protein?

In biochemistry, the native state of a protein is its properly folded and assembled form with operative structure and function. The native state of a protein needs all four levels of biomolecular structure, with secondary to quaternary structure formed by weak interactions along the covalently-bonded backbone.

What is two-state folding?

The folding of some proteins appears to be a two-state kinetic process. A two-state kinetic model is justified if protein molecules rapidly equilibrate between different unfolded conformations prior to complete folding.